HIGH THROUGHPUT PHENOTYPIC SCREENING  FOR IMMUNO-MODULATORY PROPERTIES

We use phenotypic high-throughput drug screens, also called chemical genetic or in vivo screens, to investigate the ability of individual compounds from a collection to inhibit a biological process or disease model in live cells or intact organisms. DeepSense is applying these methods to screen its compound libray for immuno-modulatory properties in specific diseases.

Innate and Adaptive Immune Memory.jpg
 

optimizing bioavailability by prodrug design

Bioavailability of naturally extracted compounds such as flavonoids has remained poor, and limiting their use in humans.


Prodrug designs have recently emerged as favored approaches in the field of drug delivery, especially transepithelial drug delivery. A prodrug is a pharmacologically inactive derivative of an active drug that undergoes in vivo biotransformation to release the active drug. 


The DeepSense prodrugs have been optimized to achieve optimum physical and chemical properties in terms of membrane permeation, bioavailbility, and stability.

By means of rational design and computaional cehmistry algorithms, we have developed selective drug-delivery systems that can facilitate permeation of low molecular weight derivatives through epithelial tissue for topical and systemic delivery. 

prodrug.jfif
 

Research Areas

Bioactive phytochemicals, in particular flavonoids, are natural antioxidants shown to be highly effiective and less toxic than conventional chemical formulations  to prevent or treat inflammatory diseases (e.g. many cancers such liver cancer, melanoma or colon cancer, atherosclerosis, auto-immune diseases, viral and bacterial infections).

Autoinflammatory Diseases
Cancer
Male Scientist
Scientist on Computer
Scientist
Scientist on Tablet
Science Lab