Circadian Rhythms are Key to Health
Aging involves multiple biological pathways acting simultaneously, and current interventions often fall short because they address only singular causes. Recent discoveries reveal that circadian rhythms, present in most cells, orchestrate essential life functions and play a crucial role in the aging process.
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Circadian rhythms regulate nearly every aspect of aging, including bioenergetic, neurologic, and metabolic health. Disruptions to these rhythms can lead to oxidative stress, inflammation, and microbiome alterations, which are linked to various health issues such as Alzheimer’s disease, metabolic syndrome, obesity, and depression.
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Restoring circadian function offers a promising new approach to addressing chronic conditions and promoting healthy aging. As we age, our daily rhythms often shift due to environmental factors, leading to reduced amplitude in circadian oscillations. This disruption is associated with inflammation, oxidative stress, and age-related diseases like depression, cognitive disorders, physical decline, and skin issues
Unlocking Youth: How Circadian Rhythms and Bioflavonoids Transform the Aging Process
Circadian Rhythm Disruptions
Accelerate Aging
Researchers, have shown that daily rhythm tends to change with age and environmental factors.
The amplitude, that is highest point of the circadian oscillation, during a 24hr cycle, shortens, with age.
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Disrupted rhythms are linked to inflammation, oxidation, and many age-related diseases such as depression, cognition disorders, physical decline, cancer, metabolic disorder, microbiome imbalances, and skin pathogenesis.
Our Goal is to Restore Diminishing Rhythms to prevent Age -Decline
Scientists screened a quarter million compounds, to discover a promising group of compounds bioflavonoids, that bind & control clock genes to affect many biological pathways:
Anti-inflammatory, anticancer, antioxidant, neuroprotective, metabolic and cardio-protective
Unique Mechanism of Action; Binding & Controlling Clock Genes to Improve Health Markers
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Aging, unhealthy. adults display dampened circadian amplitudes
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VITAMIN P™ easily absorbs into tissues , binding to Retinoic Orphan Receptor (ROR), which regulate clock genes
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Key longevity, bioenergy, immune, & metabolic targets, are subject to rhythmicity
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Addressing Bioavailability
Most bioflavonoids have low stability, permeability and solubility, in addition to poor bioavailability, and therefore, the benefits of bioflavonoids observed in animals are difficult to achieve in humans.
A lipid-based non-toxic delivery system is combined with pharmacologically active compound PMF (ex; nobiletin) improves delivery thruough the stratum corneum layer, to reach the keratinocytes.
Upon exposure to a physiologic environment in the epidermis, the pharmacologically active compound released and elicits its therapeutic benefits.
Lipid Encapsulation Technology Transforms Citrus-Derived Flavonoids into Bioavailable Functional Substances
Addressing the Hallmarks of Aging with Chronosense
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